"Traveling the Long Road to Clinical Translation of Tissue Engineered Bone Grafts"
Abstract: The treatment of large craniofacial bone loss due to congenital defects, trauma or cancer resection remains a huge clinical challenge There are approximately two hundred thousand fractures requiring bone transplantation annually in the US at an economic burden of $2B. Tissue engineering, where the patients own cells are combined with porous scaffolds to guide their development into new bone tissue, provides a viable means of obtaining ‘autologous' bone grafts for the treatment of large bone defects Successful application of tissue engineered grafts however requires that we overcome key scientific, regulatory, and practical hurdles To address these, my lab has focused on the development of a point of care stem cell biomaterial based strategy for treating massive craniomaxillofacial bone loss In this talk, I will describe the novel strategies that my lab is developing to obtain a deeper understanding of cell fates within regenerating bone and to take our bone tissue engineering approaches closer to human clinical trials.
Speaker: Professor Warren Grayson
Biomedical Engineering, Material Sciences & Engineering
Johns Hopkins University
First PhD Graduate of Professor Teng Ma
Bio: Dr. Warren Grayson is an Associate Professor of Biomedical Engineering, Material Sciences Engineering, and Chemical Biomolecular Engineering at Johns Hopkins University, a founding member of the Translational Tissue Engineering Center, and an affiliate member of the Institute for NanoBioTechnology His work on reconstructing personalized, craniofacial bone grafts has received widespread public attention with commentaries in the Scientific American BBC and the New York Times, and has spawned the start up company, EpiBone His more recent studies have focused on 3D-printing of composite, oxygen delivering scaffolds for bone repair and regenerating vascularized skeletal muscle grafts He has received Young Investigator awards from the Maryland Science Foundation and the international tissue engineering and regenerative medicine society (TERMIS) Career Development Awards from the American Society for Bone and Mineral Research and the Orthopaedic Research Society, and the prestigious National Science Foundation Early Faculty CAREER Award He was recently elected a fellow of the American Institute for Medical and Biological Engineering (AIMBE).