Jingjiao Guan
Associate Professor
(850) 410-6643


  • Ph.D., Biomedical Engineering, The Ohio State University, 2005
  • M.S., Biophysics, The Ohio State University, 2003
  • M.E., Materials Physics, University of Science and Technology, Beijing, China, 1998
  • B.E., Metal Physics, University of Science and Technology, Beijing, China, 1995

Research Interests

  • Micro/nano-devices for biosensing and drug delivery

Professional Affiliations & Qualifications

  • Postdoctoral Associate, National Science Foundation (NSF) Nanoscale Science and Engineering Center for Affordable Nanoengineering of Polymeric Biomedical Devices, The Ohio State University

Professional Memberships

  • Biomedical Engineering Society (BMES)
  • American Institute of Chemical Engineers (AIChE)
  • Materials Research Society (MRS)


  • New Investigator Award from the James and Esther King Biomedical Program of the Florida Department of Health, 2010
  • Outstanding Postdoctoral Student Majoring in Chemical Engineering, The American Institute of Chemists Foundation, 2008


Peer-reviewed Journal Articles: (* indicates corresponding author)

  1. Junfei Xia, Zhibin Wang, Yuanwei Yan, Zhijian Cheng, Li Sun, Yan Li, Yi Ren, and Jingjiao Guan*. Catalase-Laden Microdevices for Cell-Mediated Enzyme Delivery. Langmuir (2016) 32: 13386-13393.
  2. Yuanwei Yan, Julie Bejoy, Junfei Xia, Jingjiao Guan, Yi Zhou, Yan Li, Neural patterning of human induced pluripotent stem cells in 3-D cultures for studying biomolecule-directed differential cellular responses. Acta Biomaterialia (2016) 42: 114-126.
  3. Junfei Xia, Zhibin Wang, Danting Huang, Yuanwei Yan, Yan Li, Jingjiao Guan*. Asymmetric biodegradable microdevices for cell-borne drug delivery. ACS Applied Materials Interfaces (2015) 7(11): 6293-6299.
  4. Peipei Zhang, Yong Qiao, Junfei Xia, Jingjiao Guan, Liyuan Ma, Ming Su. Enhanced radiation therapy with multilayer microdisks containing radiosensitizing gold nanoparticles. ACS Applied Materials Interfaces (2015) 7(8): 4518-4524.
  5. Zhibin Wang, Junfei Xia, Yuanwei Yan, Ang-Chen Tsai, Yan Li, Teng Ma, Jingjiao Guan*. Facile functionalization and assembly of live cells with microcontact-printed polymeric biomaterials. ACS Applied Materials Interfaces (2015) 11: 80-87.
  6. Junfei Xia, Zhibin Wang, Danting Huang, Peipei Zhang, Brett Kirkland, Jingjiao Guan*. Self-referenced detection of Cu2+ using a crossbar array of protein-stabilized gold nanocluster and a thermoplastic. Science Letters Journal (2015) 4: 196.
  7. Zhibin Wang, Junfei Xia, Sida Luo, Peipei Zhang, Zhiwei Xiao, Tao Liu, Jingjiao Guan*, Versatile surface micropatterning and functionalization enabled by microcontact printing of poly(4-aminostyrene), Langmuir (2014) 30: 13483-13490.
  8. Waris Obitayo, Sida Luo, Zhiwei Xiao, Tao Liu*, Jingjiao Guan*, Gel electrophoresis and Raman mapping for determining the length distribution of SWCNTs, RSC Advances (2014) 4: 37070-37078.
  9. Peipei Zhang, Junfei Xia, Zhibin Wang, Jingjiao Guan*, Gold nanoparticles-packed microdisks for multiplex Raman labelling of cells, Nanoscale (2014) 6: 8762-8768.
  10. Zhibin Wang, Junfei Xia, Jingjiao Guan*, Micro/nanocontact printing of water-soluble biomacromolecules and polymers, Science Letters Journal (2014) 3: 58.
  11. Troy W. Lowry, Aubrey Kusi-Appiah, Jingjiao Guan, David van Winkle, Michael Davidson, Steven Lenhert, Materials Integration by Nanointaglio, Advanced Materials Interfaces (2014) 1: 1300127.
  12. Zhibin Wang, Jingfang Wang, Zhiwei Xiao, Junfei Xia, Peipei Zhang, Tao Liu, Jingjiao Guan∗, A Paper Indicator for Triple-modality sensing of nitrite based on colorimetric assay, Raman spectroscopy, and electron paramagnetic resonance spectroscopy, Analyst (2013) 138: 7303-7307.
  13. Danting Huang, Zhibin Wang, Junfei Xia, Peipei Zhang, Brett Kirkland, Anant Paravastu*, Jingjiao Guan*, Microcontact printing of Alzheimer’s β-amyloid monomers and fibrils, European Polymer Journal, 2013, 49 (10): 3052-3059.
  14. Brett Kirkland, Zhibin Wang, Peipei Zhang, Shin-ichiro Takebayashi, Steven Lenhert, David M. Gilbert, Jingjiao Guan∗, Low-cost fabrication of centimetre-scale periodic arrays of single plasmid DNA molecules, Lab on a Chip, (2013) 13: 3367-3372.
  15. Yingru Liu, Brett Kirkland, James Shirley, Zhibin Wang, Peipei Zhang, Jacquelyn Stembridge, Wilson Wong, Shin-ichiro Takebayashi, David M. Gilbert, Steven Lenhert, Jingjiao Guan*, Development of single-cell array for large-scale DNA fluorescence in situ hybridization, Lab on a Chip (2013) 13: 1316-1324.
  16. Peipei Zhang, Yingru Liu, Junfei Xia, Zhibin Wang, Brett Kirkland, Jingjiao Guan*, Top-down fabrication of polyelectrolyte-thermoplastic hybrid microparticles for unidirectional drug delivery to single cells, Advanced Healthcare Materials (2013) 2: 540-545.
  17. Zhibin Wang, Peipei Zhang, Brett Kirkland, Yingru Liu, Jingjiao Guan*, Microcontact printing of polyelectrolytes on PEG using an unmodified PDMS stamp for micropatterning nanoparticles, DNA, proteins and cells, Soft Matter (2012) 8: 7630-7637.
  18. Xiaozhu Wang, Shin-ichiro Takebayashi, Evans Bernardin, David M. Gilbert, Ravindran Chella, Jingjiao Guan*, Microfluidic extraction and stretching of chromosomal DNA from single cell nuclei for DNA fluorescence in situ hybridization, Biomedical Microdevices (2012) 14: 443-451.
  19. Peipei Zhang, Jingjiao Guan*, Fabrication of Multilayered Microparticles by Integrating Layer-by-Layer Assembly and MicroContact Printing, Small (2011) 7: 2998–3004.
  20. Jingjiao Guan, Pouyan E. Boukany, Orin Hemminger, Nan-Rong Chiou, Weibin Zha, Megan Cavanaugh, L. James Lee, Large laterally ordered nanochannel arrays from DNA combing and imprinting, Advanced Materials (2010) 22: 3997–4001.
  21. Chung Hsun Lin, Jingjiao Guan, Shiu Wu Chau, Shia Chung Chen, L. James Lee, Patterning nanowire and micro-/nanoparticle array on micropillar-structured surface: Experiment and modeling, Biomicrofluidics (2010) 4: 034103-1-14.
  22. Chee Guan Koh, Xulang Zhang, Shujun Liu, Sharon Golan, Bo Yu, Xiaojuan Yang, Jingjiao Guan, Yan Jin, Yeshayahu Talmon, Natarajan Muthusamy, Kenneth K Chan, John C. Byrd, Robert J. Lee, Guido Marcucci, L. James Lee, Delivery of antisense oligodeoxyribonucleotide lipopolyplex nanoparticles assembled by microfluidic hydrodynamic focusing, Journal of Controlled Release (2010) 141: 62-69.
  23. Chee Guan Koh, Xihai Kang, Yubing Xie, Zhengzheng Fei, Jingjiao Guan, Bo Yu, Xulang Zhang, L. James Lee, Delivery of polyethylenimine/DNA complexes assembled in a microfluidics device, Molecular Pharmaceutics (2009) 6: 1333-1342.
  24. C H Lin, J Guan, S W Chau, L J Lee, Experimental and numerical analysis of DNA nanostrand array formation by molecular combing on microwell-patterned surface, Journal of Physics D: Applied Physics (2009) 42: 025303.
  25. Xiaogang Pan, Jingjiao Guan, Jung-Woo Yoo, Arthur J. Epstein, L. James Lee, Robert J. Lee, Cationic lipid-coated magnetic nanoparticles associated with transferrin for gene delivery. International Journal of Pharmaceutics, (2008) 358: 263-270.
  26. Prashant Pradhan, Jingjiao Guan, Dongning Lu, Peng George Wang, L. James Lee, Robert J. Lee*, A Facile microfluidic method for production of liposomes, Anticancer Research, (2008) 28: 943-948. Co-first author.
  27. Shengnian Wang, Jingjiao Guan, L. James Lee, Flow-guided assembly processes, ChemPhysChem, (2008) 9:967-973.
  28. Jingjiao Guan, Nicholas Ferrell, Bo Yu, Derek J. Hansford, L. James Lee, Simultaneous generation of hybrid arrays of micro/nanoparticles and nanowires by dewetting on micropillars, Soft Matter (2007) 2: 1369-1371. Cover article.
  29. Nan-Rong Chiou, Chunmeng Lu, Jingjiao Guan, L. James Lee, Arthur J. Epstein, Growth and alignment of polyaniline nanofibres with superhydrophobic, superhydrophilic and other properties, Nature Nanotechnology (2007) 2: 354-357.
  30. Jingjiao Guan, Bo Yu, L. James Lee, Forming highly ordered arrays of functionalized polymer nanowires by dewetting on micropillars, Advanced Materials (2007) 19: 1212-1217.
  31. Jingjiao Guan, Hongyan He, Derek Hansford, L. James Lee, Fabrication of particulate reservoir-containing, capsule-like, and self-foldable polymer microstructures for drug delivery, Small (2007) 3: 412-418.
  32. Hongyan He, Jingjiao Guan, L. James Lee, An oral delivery device based on self-folding hydrogels, Journal of Controlled Release (2006) 110: 339-346.
  33. Jingjiao Guan, Nick Ferrell, L. James Lee, Derek Hansford, Fabrication of polymeric microparticles for drug delivery by soft Lithography, Biomaterials (2006) 27: 4034-4041.
  34. Jingjiao Guan, L. James Lee, Generating highly ordered DNA nanostrand array, Proceedings of National Academy of Science, U. S. A. (2005) 102: 18321-18325. Prominently featured on the cover and in a "This Week in PNAS" introductory article. Reported on science news websites worldwide.
  35. Jingjiao Guan, Hongyan He, L. James Lee, Derek J. Hansford, Self-Folding of hydrogel three dimensional microstructures, Journal of Physical Chemistry B (2005) 109: 23134-23137.
  36. Jingjiao Guan, Aravind Chakrapani, Derek J. Hansford, Polymer microparticles fabricated by soft lithography, Chemistry of Materials (2005) 17: 6227-6229.
  37. Yi-Je Juang, Xin Hu, Shengnian Wang, L. James Lee, Chunmeng Lu, Jingjiao Guan, Electrokinetic interactions in microscale cross-slot flow, Applied Physics Letters (2005) 87: 244105-1-3.
  38. Junwei Li, Chen Wang, Guangyi Shang, Qingmin Xu, Zhang Lin, Jingjiao Guan, Chunli Bai, Friction coefficients derived from apparent height variations in contact mode atomic force microscopy images, Langmuir (1999) 15: 7662-7669.
  39. Jingjiao Guan, Chen Wang, Wuyang Chu, Atomic structure of loaded crack tip by AFM, Scripta Materialia (1998) 39: 1211-1214.
  40. Ming Su, Chunli Bai, Chen Wang, Jingjiao Guan, Substrate-dependent dispersion behavior of polymer-protected Pt colloid studied by SPM, Applied Surface Science (1998) 133: 23 -26.
  41. Mingzhang Wang, Shi Lin, Jinxu Li, Jingjiao Guan, Jimei Xiao, Fatigue damage and crack initiation in [112] aluminum single Crystal, Jinshu Xuebao (1997) 33: 1015.

Book Chapters:

  1. Jingjiao Guan, Chapter: Microcontact printing, Book: The Nanobiotechnology Handbook, Publisher: CRC Press, ISBN-10: 1439838690, Editor: Yubing Xie, 2012.
  2. Jingjiao Guan, L. James Lee, Chapter: Guided Assembly by Surface Controlled Dewetting and Evaporation, Book: Evaporative Self-Assembly of Ordered Complex Structures, Publisher: World Scientific Publishing Company, Singapore. To be published.
  3. Jingjiao Guan, Xiaogang Pan, L. James Lee, Robert J. Lee, Chapter: Viral, Non-Viral and Physical Methods for Gene Delivery, Book: Biopharmaceutical Drug Design and Development, Publisher: Humana Press, (2008) 141-174.
  4. Jingjiao Guan, Hongyan He, Bo Yu, L. James Lee, Chapter: Polymeric Nanostructures for Controlled Drug and Gene Delivery, Book: Biomedical Nanostructures, Publisher: John Wiley & Sons, (2008) 115-137.